Biochemical and functional analysis of innexin2-containing gap junction channels during organogenesis in Drosophila
نویسنده
چکیده
Diese Dissertation ist auf dem Hochschulschriftenserver der ULB Bonn unter junction communication and paracrine signaling pathways during organogenesis in Drosophila. (2006). DE-cadherin, a core component of the adherens junction complex modifies subcellular localization of the Drosophila gap junction protein innexin2. Intercellular communication: the Drosophila innexin multiprotein family of gap junction proteins.
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Heteromerization of innexin gap junction proteins regulates epithelial tissue organization in Drosophila.
Gap junctions consist of clusters of intercellular channels, which enable direct cell-to-cell communication and adhesion in animals. Whereas deuterostomes, including all vertebrates, use members of the connexin and pannexin multiprotein families to assemble gap junction channels, protostomes such as Drosophila and Caenorhabditis elegans use members of the innexin protein family. The molecular c...
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Germ cells require intimate associations with surrounding somatic cells during gametogenesis. During oogenesis, gap junctions mediate communication between germ cells and somatic support cells. However, the molecular mechanisms by which gap junctions regulate the developmental processes during oogenesis are poorly understood. We have identified a female sterile allele of innexin2 (inx2), which ...
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Members of the innexin protein family are structural components of invertebrate gap junctions and are analogous to vertebrate connexins. Here we investigate two Drosophila innexin genes, Dm-inx2 and Dm-inx3 and show that they are expressed in overlapping domains throughout embryogenesis, most notably in epidermal cells bordering each segment. We also explore the gap-junction-forming capabilitie...
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